Locate the new 'Spyder3Express.icm' file for the second monitor and make a copy of it in the same directory, in my case 'Spyder3Express-FP222W-20121005.icm'. Repeat Steps 3-5 as above but this time select monitor 2 as shown below and calibrate it in the same way. Locate the newly created file 'Spyder3Express.icm' and make a copy of it in the same directory, in my case 'Spyder3Express-AOC2236-20121005.icm'. Using file explorer, navigate to the profiles directory 'C:\Windows\System32\spool\drivers\color'.
Perform a standard SpyderExpress calibration procedure on the selected monitor and confirm colour has been corrected as expected. Go into Screen Resolution settings (right click on the desktop) and change the display to only use monitor 1 as shown.
Install the SpyderX Express drivers and software but do not begin any calibration. Get your dual monitor desktop configured and working the way you want.
Feel free to ask questions if this does not work for you. I apologize for this rather terse set of instructions. Here is my successful solution providing monitor independent calibration for two monitors, an AOC and a BENQ. Rather than being forced to pay for an upmarket product with multiple monitor support I decided to find a work-around. The 'Express' is an inexpensive entry level product designed only to support a single monitor. Looking for help on this issue I kept getting the same message that I need to pay double for the model which does support multiple monitors. Recently however I upgraded to a new Windows7 dual monitor desktop and officially the Spyder3 Express no longer worked for me. SpyderX assures you of support for recent resolutions, gamuts and screen types.I have been using my trusted Spyder3 Express in a WindowsXP environment for a few years now to calibrate my monitors and ensure consistent colour and tone rendering between computers.